Gageostatin C

General Information


DRACP ID  DRACP02622

Peptide Name   Gageostatin C

Sequence  ELLVDLL

Sequence Length  7

UniProt ID  Not available

PubChem CID  139583883 

Origin  Bacillus subtilis

Type  Native peptide

Classification

  

Active ACP Lipopeptides



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
MDA-MB-231 Breast adenocarcinoma Carcinoma IC50=11.2 µg/mL SBR assay 48 h 1
HCT 15 Colon adenocarcinoma Carcinoma IC50=23.2 µg/mL SBR assay 48 h 1
PC-3 Prostate carcinoma Carcinoma IC50=11.7 µg/mL SBR assay 48 h 1
NCI-H23 Lung adenocarcinoma Carcinoma IC50=10.9 µg/mL SBR assay 48 h 1
NUGC-3 Gastric adenocarcinoma Carcinoma IC50=10.5 µg/mL SBR assay 48 h 1
ACHN Papillary renal cell carcinoma Carcinoma IC50=12.3 µg/mL SBR assay 48 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial; Antifungal



Structure Information


PDB ID  Not available

Predicted Structure  DRACP02622

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  (E)-7,9-dimethylundec-2-enoic acid

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C38H67N7O12

Absent amino acids  ACFGHIKMNPQRSTWY

Common amino acids  L

Mass  92121

Pl  3.55

Basic residues  0

Acidic residues  2

Hydrophobic residues  5

Net charge  -2

Boman Index  819

Hydrophobicity  177.14

Aliphatic Index  264.29

Half Life 
  Mammalian: 1 hour
  Yeast: 30 min
  E.coli: >10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  0

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 24492520

Title  Gageostatins A-C, antimicrobial linear lipopeptides from a marine Bacillus subtilis

Doi 10.3390/md12020871

Year  2014

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPN_5451

DRACP is developed by Dr.Zheng's team.