This work is licensed under a Creative Commons Attribution 4.0 International License.
Ranatuerin-2VLb
General Information
DRACP ID DRACP02623
Peptide Name Ranatuerin-2VLb
Sequence GIMDTIKGAAKDLAGQLLDKLKCKITKC
Sequence Length 28
UniProt ID Not available
PubChem CID Not available
Origin Lithobates vaillanti
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HepG2 | Hepatoblastoma | Blastoma | LC50=30 µM | CytoTox 96 non-radiactive cytotoxicity assay | 1 h | 1 |
Hemolytic Activity Huµan erythrocytes: HC50>200 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys23<--->Cys28
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C129H231N35O38S3
Absent amino acids EFHNPRSVWY
Common amino acids K
Mass 345848
Pl 9.51
Basic residues 6
Acidic residues 3
Hydrophobic residues 10
Net charge 3
Boman Index -2254
Hydrophobicity 3.57
Aliphatic Index 108.21
Half Life
Mammalian: 1 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 125
Absorbance 280nm 4.63
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 19379837
Title Purification of peptides with differential cytolytic activities from the skin secretions of the Central American frog, Lithobates vaillanti (Ranidae)
Doi 10.1016/j.cbpc.2009.04.003
Year 2009
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.