This work is licensed under a Creative Commons Attribution 4.0 International License.
Brevinin-1VLa
General Information
DRACP ID DRACP02624
Peptide Name Brevinin-1VLa
Sequence FLGAIAGVAAKFLPKVFCFITKKC
Sequence Length 24
UniProt ID Not available
PubChem CID Not available
Origin Lithobates vaillanti
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HepG2 | Hepatoblastoma | Blastoma | LC50=4 µM | CytoTox 96 non-radiactive cytotoxicity assay | 1 h | 1 |
Hemolytic Activity Huµan erythrocytes: HC50=8 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys18<--->Cys24
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C125H198N28O26S2
Absent amino acids DEHMNQRSWY
Common amino acids AFK
Mass 298369
Pl 10.35
Basic residues 4
Acidic residues 0
Hydrophobic residues 14
Net charge 4
Boman Index 2659
Hydrophobicity 123.75
Aliphatic Index 105.83
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 125
Absorbance 280nm 5.43
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 19379837
Title Purification of peptides with differential cytolytic activities from the skin secretions of the Central American frog, Lithobates vaillanti (Ranidae)
Doi 10.1016/j.cbpc.2009.04.003
Year 2009
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.