Brevinin-1VLd

General Information


DRACP ID  DRACP02625

Peptide Name   Brevinin-1VLd

Sequence  FLPLIAGVAANFLPKIFCLISKKC

Sequence Length  24

UniProt ID  Not available

PubChem CID  Not available

Origin  Lithobates vaillanti

Type  Native peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HepG2 Hepatoblastoma Blastoma LC50=4 µM CytoTox 96 non-radiactive cytotoxicity assay  1 h 1

Hemolytic Activity  Huµan erythrocytes: HC50=7 µM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial; Antifungal



Structure Information


PDB ID  Not available

Predicted Structure  DRACP02625

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Cys18<--->Cys24

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C126H204N28O27S2

Absent amino acids  DEHMQRTWY

Common amino acids  L

Mass  301775

Pl  9.67

Basic residues  3

Acidic residues  0

Hydrophobic residues  14

Net charge  3

Boman Index  2966

Hydrophobicity  133.75

Aliphatic Index  138.33

Half Life 
  Mammalian: 1.1 hour
  Yeast: 3 min
  E.coli: 2 min

Extinction Coefficient cystines  125

Absorbance 280nm  5.43

Polar residues  5

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 19379837

Title  Purification of peptides with differential cytolytic activities from the skin secretions of the Central American frog, Lithobates vaillanti (Ranidae)

Doi 10.1016/j.cbpc.2009.04.003

Year  2009

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.