Brevinin-1VLc

General Information


DRACP ID  DRACP02626

Peptide Name   Brevinin-1VLc

Sequence  FLPVIASVAAKVLPKVFCFITKKC

Sequence Length  24

UniProt ID  Not available

PubChem CID  Not available

Origin  Lithobates vaillanti

Type  Native peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HepG2 Hepatoblastoma Blastoma LC50=6 µM CytoTox 96 non-radiactive cytotoxicity assay  1 h 1

Hemolytic Activity  Huµan erythrocytes: HC50=5 µM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial; Antifungal



Structure Information


PDB ID  Not available

Predicted Structure  DRACP02626

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Cys18<--->Cys24

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C127H208N28O27S2

Absent amino acids  DEGHMNQRWY

Common amino acids  KV

Mass  303378

Pl  10.35

Basic residues  4

Acidic residues  0

Hydrophobic residues  14

Net charge  4

Boman Index  2460

Hydrophobicity  132.92

Aliphatic Index  125.83

Half Life 
  Mammalian: 1.1 hour
  Yeast: 3 min
  E.coli: 2 min

Extinction Coefficient cystines  125

Absorbance 280nm  5.43

Polar residues  4

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 19379837

Title  Purification of peptides with differential cytolytic activities from the skin secretions of the Central American frog, Lithobates vaillanti (Ranidae)

Doi 10.1016/j.cbpc.2009.04.003

Year  2009

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.