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B1-C10
General Information
DRACP ID DRACP02628
Peptide Name B1-C10
Sequence VKRFKKFFRKLKKSV
Sequence Length 15
UniProt ID B6D434
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Lipopeptides Membrane lysis Induce apoptosis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=9.1 ± 0.7 µM | MTT assay | 48 h | 1 |
| MCF-7/Taxol | Invasive breast carcinoma of no special type | Carcinoma | IC50=10.5 ± 1.3 µM | MTT assay | 48 h | 1 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | Leukemia | IC50=11.0 ± 1.1 µM | MTT assay | 48 h | 1 |
| K562/ADM | Blast phase chronic myelogenous leukemia, BCR-ABL11 positive; Chronic myeloid leukemia | Leukemia | IC50=11.7 ± 0.7 µM | MTT assay | 48 h | 1 |
Hemolytic Activity Human erythrocytes: <20% Hemolysis =160 µM
Normal (non-cancerous) Cytotoxicity GES-1: IC50=81.3 ± 6.8 µM; HEK293: IC50=81.3 ± 6.8 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification CH3(CH2)8CO, Decanoic acid
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C94H159N27O17
Absent amino acids ACDEGHIMNPQTWY
Common amino acids K
Mass 218934
Pl 12.58
Basic residues 8
Acidic residues 0
Hydrophobic residues 6
Net charge 8
Boman Index -4460
Hydrophobicity -84
Aliphatic Index 64.67
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26083110
Title Aliphatic acid-conjugated antimicrobial peptides--potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.