B1-C14

General Information


DRACP ID  DRACP02630

Peptide Name   B1-C14

Sequence  VKRFKKFFRKLKKSV

Sequence Length  15

UniProt ID  B6D434 

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP Lipopeptides Membrane lysis Induce apoptosis



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
MCF-7 Invasive breast carcinoma of no special type Carcinoma IC50=3.2 ± 0.2 µM MTT assay 48 h 1
MCF-7/Taxol Invasive breast carcinoma of no special type Carcinoma IC50=3.2 ± 0.4 µM MTT assay 48 h 1
K562 Blast phase chronic myelogenous leukemia, BCR-ABL3 positive; Chronic myeloid leukemia Leukemia IC50=6.6 ± 0.3 µM MTT assay 48 h 1
K562/ADM Blast phase chronic myelogenous leukemia, BCR-ABL13 positive; Chronic myeloid leukemia Leukemia IC50=4.9 ± 0.1 µM MTT assay 48 h 1

Hemolytic Activity  Human erythrocytes: <20% Hemolysis =160 µM

Normal (non-cancerous) Cytotoxicity  GES-1: IC50=70.8 ± 7.1 µM; HEK293: IC50=70.2 ± 5.0 µM

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP02630

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  CH3(CH2)12CO, Myristic acid

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C94H159N27O17

Absent amino acids  ACDEGHIMNPQTWY

Common amino acids  K

Mass  218934

Pl  12.58

Basic residues  8

Acidic residues  0

Hydrophobic residues  6

Net charge  8

Boman Index  -4460

Hydrophobicity  -84

Aliphatic Index  64.67

Half Life 
  Mammalian: 100 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  1

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 26083110

Title  Aliphatic acid-conjugated antimicrobial peptides--potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability

Doi 10.1039/c5ob00752f

Year  2015

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.