This work is licensed under a Creative Commons Attribution 4.0 International License.
R7L
General Information
DRACP ID DRACP02641
Peptide Name R7L
Sequence LRPLLRPLLRPLLRPLLRPLLRPLLRPL
Sequence Length 28
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| RAW 264.7 | Mouse leukemia | Leukemia | IC50=2.295 µM | MTT assay | 18-24 h | 1 |
Hemolytic Activity Human erythrocytes: HC10=64 µM
Normal (non-cancerous) Cytotoxicity HEK 293T: IC50=19.21 μM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C161H289N49O29
Absent amino acids ACDEFGHIKMNQSTVWY
Common amino acids L
Mass 385715
Pl 13.28
Basic residues 7
Acidic residues 0
Hydrophobic residues 14
Net charge 7
Boman Index -3556
Hydrophobicity 37.5
Aliphatic Index 195
Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30742437
Title Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria
Doi 10.1021/acs.jmedchem.8b01348
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.