This work is licensed under a Creative Commons Attribution 4.0 International License.
Cecropin (1-12) [I8A, E9A, V11K]
General Information
DRACP ID DRACP02643
Peptide Name Cecropin (1-12) [I8A, E9A, V11K]
Sequence RWKIFKKAAKKG
Sequence Length 12
UniProt ID P14666
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| RAW 264.7 | Mouse leukemia | Leukemia | Not active up to 50 µM | MTT assay | Not available | 1 |
Hemolytic Activity Human erythrocytes: HC10=200 µM
Normal (non-cancerous) Cytotoxicity HaCat: Not active up to 50 µM; HEK293: Not active up to 50 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C70H117N21O13
Absent amino acids CDEHLMNPQSTVY
Common amino acids K
Mass 165722
Pl 12.05
Basic residues 6
Acidic residues 0
Hydrophobic residues 5
Net charge 6
Boman Index -2788
Hydrophobicity -120
Aliphatic Index 49.17
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 500
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30846839
Title Development of a novel short 12-meric papiliocin-derived peptide that is effective against Gram-negative sepsis
Doi 10.1038/s41598-019-40577-8
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.