This work is licensed under a Creative Commons Attribution 4.0 International License.
Mastoparan
General Information
DRACP ID DRACP02656
Peptide Name Mastoparan
Sequence INLKALAALAKKIL
Sequence Length 14
UniProt ID Not available
PubChem CID Not available
Origin Vespula lewisii
Type Synthetic peptide
Classification
Active ACP Cell-penetrating peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=5 µM | MTT assay | 20 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Ethylamine
Other Modification None
Chiral L
Physicochemical Information
Formula C70H130N18O16
Absent amino acids CDEFGHMPQRSTVWY
Common amino acids AL
Mass 171201
Pl 11.1
Basic residues 3
Acidic residues 0
Hydrophobic residues 10
Net charge 3
Boman Index 1347
Hydrophobicity 115.71
Aliphatic Index 195.71
Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26114809
Title Sequence-activity relationship, and mechanism of action of mastoparan analogues against extended-drug resistant Acinetobacter baumannii
Doi 10.1016/j.ejmech.2015.06.016
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.