Peptide F1

General Information


DRACP ID  DRACP02658

Peptide Name   Peptide F1

Sequence  GKKLGLWLGLKKG

Sequence Length  13

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
RAW 264.7 Mouse leukemia Leukemia <20% Killing=2-128 µM MTT assay 24 h 1

Hemolytic Activity  Human erythrocytes: <5% Hemolysis=128 µM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  Not available

Predicted Structure  DRACP02658

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C67H116N18O14

Absent amino acids  ACDEFHIMNPQRSTVY

Common amino acids  GKL

Mass  161201

Pl  11.28

Basic residues  4

Acidic residues  0

Hydrophobic residues  5

Net charge  4

Boman Index  357

Hydrophobicity  -22.31

Aliphatic Index  120

Half Life 
  Mammalian: 20 hour
  Yeast: 30 min
  E.coli: >10 hour

Extinction Coefficient cystines  5500

Absorbance 280nm  458.33

Polar residues  4

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 30919848

Title  Short, symmetric-helical peptides have narrow-spectrum activity with low resistance potential and high selectivity

Doi 10.1039/c9bm00044e

Year  2019

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.