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Peptide F1
General Information
DRACP ID DRACP02658
Peptide Name Peptide F1
Sequence GKKLGLWLGLKKG
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| RAW 264.7 | Mouse leukemia | Leukemia | <20% Killing=2-128 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: <5% Hemolysis=128 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C67H116N18O14
Absent amino acids ACDEFHIMNPQRSTVY
Common amino acids GKL
Mass 161201
Pl 11.28
Basic residues 4
Acidic residues 0
Hydrophobic residues 5
Net charge 4
Boman Index 357
Hydrophobicity -22.31
Aliphatic Index 120
Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 458.33
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30919848
Title Short, symmetric-helical peptides have narrow-spectrum activity with low resistance potential and high selectivity
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.