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Peptide F12
General Information
DRACP ID DRACP02669
Peptide Name Peptide F12
Sequence KKLGLCLGLKK
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| RAW 264.7 | Mouse leukemia | Leukemia | <20% Killing=2-128 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: <5% Hemolysis=128 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C55H105N15O12S
Absent amino acids ADEFHIMNPQRSTVWY
Common amino acids KL
Mass 137916
Pl 10.8
Basic residues 4
Acidic residues 0
Hydrophobic residues 4
Net charge 4
Boman Index 64
Hydrophobicity 11.82
Aliphatic Index 141.82
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30919848
Title Short, symmetric-helical peptides have narrow-spectrum activity with low resistance potential and high selectivity
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.