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Kunitzin-RE (1-11) TWS-1
General Information
DRACP ID DRACP02684
Peptide Name Kunitzin-RE (1-11) TWS-1
Sequence AARRILRWIFR
Sequence Length 11
UniProt ID L0NP29
PubChem CID Not available
Origin Synthetic (Derived from Kunitzin-RE)
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| RAW 264.7 | Mouse leukemia | Leukemia | >90% Killing=128 µM | MTT assay | 18-24 h | 1 |
Hemolytic Activity Human erythrocytes: <10% Hemolysis=128 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C68H112N24O12
Absent amino acids CDEGHKMNPQSTVY
Common amino acids R
Mass 163634
Pl 12.98
Basic residues 4
Acidic residues 0
Hydrophobic residues 7
Net charge 4
Boman Index -3599
Hydrophobicity 2.73
Aliphatic Index 124.55
Half Life
Mammalian: 4.4 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 550
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30958004
Title Rational Design of Short Peptide Variants by Using Kunitzin-RE, an Amphibian-Derived Bioactivity Peptide, for Acquired Potent Broad-Spectrum Antimicrobial and Improved Therapeutic Potential of Commensalism Coinfection of Pathogens
Doi 10.1021/acs.jmedchem.9b00149
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.