This work is licensed under a Creative Commons Attribution 4.0 International License.
Apidaecin-1B [R4K, I8R]
General Information
DRACP ID DRACP02686
Peptide Name Apidaecin-1B [R4K, I8R]
Sequence GNNKPVYRPQPRPPHPRL
Sequence Length 18
UniProt ID P35581
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A431 | Skin squamous cell carcinoma | Carcinoma | 30% Cytotoxicity=10 µM | MTT assay | 24 h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | Not active up to 10 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C95H151N33O23
Absent amino acids ACDEFIMSTW
Common amino acids P
Mass 242683
Pl 12.23
Basic residues 5
Acidic residues 0
Hydrophobic residues 2
Net charge 5
Boman Index -6403
Hydrophobicity -191.11
Aliphatic Index 37.78
Half Life
Mammalian: 4.4 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 1490
Absorbance 280nm 87.65
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31209863
Title Identification and elucidation of proline-rich antimicrobial peptides with enhanced potency and delivery
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_13541
This work is licensed under a Creative Commons Attribution 4.0 International License.