Apidaecin-1B [R4K, I8R]

General Information


DRACP ID  DRACP02686

Peptide Name   Apidaecin-1B [R4K, I8R]

Sequence  GNNKPVYRPQPRPPHPRL

Sequence Length  18

UniProt ID  P35581 

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
A431 Skin squamous cell carcinoma Carcinoma 30% Cytotoxicity=10 µM MTT assay 24 h 1
MDA-MB-231 Breast adenocarcinoma Carcinoma Not active up to 10 µM MTT assay 24 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  Not available

Predicted Structure  DRACP02686

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C95H151N33O23

Absent amino acids  ACDEFIMSTW

Common amino acids  P

Mass  242683

Pl  12.23

Basic residues  5

Acidic residues  0

Hydrophobic residues  2

Net charge  5

Boman Index  -6403

Hydrophobicity  -191.11

Aliphatic Index  37.78

Half Life 
  Mammalian: 4.4 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  1490

Absorbance 280nm  87.65

Polar residues  4

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 31209863

Title  Identification and elucidation of proline-rich antimicrobial peptides with enhanced potency and delivery

Doi 10.1002/bit.27092

Year  2019

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_13541

DRACP is developed by Dr.Zheng's team.