This work is licensed under a Creative Commons Attribution 4.0 International License.
Pyrrhocoricin
General Information
DRACP ID DRACP02687
Peptide Name Pyrrhocoricin
Sequence VDKGSYLPRPTPPRPIYNRN
Sequence Length 20
UniProt ID P37362
PubChem CID Not available
Origin Pyrrhocoris apterus
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A431 | Skin squamous cell carcinoma | Carcinoma | <10% Cytotoxicity=10 µM | MTT assay | 24 h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | Not active up to 10 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C105H166N32O29
Absent amino acids ACEFHMQW
Common amino acids P
Mass 267972
Pl 10.64
Basic residues 4
Acidic residues 1
Hydrophobic residues 3
Net charge 3
Boman Index -6374
Hydrophobicity -139.5
Aliphatic Index 53.5
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 2980
Absorbance 280nm 156.84
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31209863
Title Identification and elucidation of proline-rich antimicrobial peptides with enhanced potency and delivery
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_13548
This work is licensed under a Creative Commons Attribution 4.0 International License.