This work is licensed under a Creative Commons Attribution 4.0 International License.
Pyrrhocoricin [L7R, R14K]
General Information
DRACP ID DRACP02688
Peptide Name Pyrrhocoricin [L7R, R14K]
Sequence VDKGSYRPRPTPPKPIYNRN
Sequence Length 20
UniProt ID P37362
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A431 | Skin squamous cell carcinoma | Carcinoma | <10% Cytotoxicity=10 µM | MTT assay | 24 h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | Not active up to 10 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C105H167N33O29
Absent amino acids ACEFHLMQW
Common amino acids P
Mass 269473
Pl 10.95
Basic residues 5
Acidic residues 1
Hydrophobic residues 2
Net charge 4
Boman Index -7421
Hydrophobicity -178
Aliphatic Index 34
Half Life
Mammalian: 100 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 2980
Absorbance 280nm 156.84
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31209863
Title Identification and elucidation of proline-rich antimicrobial peptides with enhanced potency and delivery
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_13550
This work is licensed under a Creative Commons Attribution 4.0 International License.