This work is licensed under a Creative Commons Attribution 4.0 International License.
Oncocin Onc110
General Information
DRACP ID DRACP02693
Peptide Name Oncocin Onc110
Sequence VDKPPYLPRPRPxRxXYNX
Sequence Length 19
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| SH-SY5Y | Neuroblastoma | Blastoma | <5% Cytotoxicity=600 µg/ml | MTT assay | 24 h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 20-25% Cytotoxicity=600 µg/ml | MTT assay | 24 h | 1 |
| HepG2 | Hepatoblastoma | Blastoma | Not active up to 600 µg/ml | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HEK293: Not active up to 600 µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification x=trans-4-hydroxyproline; X(16)=tert-Leu; X(19)=Orn
Chiral Mix
Physicochemical Information
Formula C86H126N26O17
Absent amino acids ACEFGHIMQSTW
Common amino acids P
Mass 233732
Pl 10.64
Basic residues 4
Acidic residues 1
Hydrophobic residues 2
Net charge 3
Boman Index -5699
Hydrophobicity -142.11
Aliphatic Index 35.79
Half Life
/
Extinction Coefficient cystines 2980
Absorbance 280nm 165.56
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26334348
Title Optimization of oncocin for antibacterial activity using a SPOT synthesis approach: extending the pathogen spectrum to Staphylococcus aureus
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.