Peptide Libraray

Oncocin Onc110 analog b

General Information

DRACP ID DRACP02695

Peptide Name Oncocin Onc110 analog b

Sequence VXKPPYLPRPRWxRxjYNX

Sequence Length 19

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
SH-SY5Y	Neuroblastoma	Blastoma	10% Cytotoxicity=600 µg/ml	MTT assay	24 h	1
HeLa	Human papillomavirus-related endocervical adenocarcinoma	Carcinoma	10-20% Cytotoxicity=600 µg/ml	MTT assay	24 h	1
HepG2	Hepatoblastoma	Blastoma	<5% Cytotoxicity=600 µg/ml	MTT assay	24 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity HEK293: Not active up to 600 µg/ml

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antibacterial

Structure Information

PDB ID Not available

Predicted Structure Not available

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification x=trans-4-hydroxyproline; X(16)=tert-Leu; X(2/19)=Orn

Chiral Mix

Physicochemical Information

Formula C88H122N26O13

Absent amino acids ACDEFGHIMQST

Common amino acids P

Mass 229331

Pl 11.47

Basic residues 4

Acidic residues 0

Hydrophobic residues 3

Net charge 4

Boman Index -4594

Hydrophobicity -120

Aliphatic Index 35.79

Half Life
/

Extinction Coefficient cystines 8480

Absorbance 280nm 471.11

Polar residues 3

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 26334348

Title Optimization of oncocin for antibacterial activity using a SPOT synthesis approach: extending the pathogen spectrum to Staphylococcus aureus

Doi 10.1007/s00726-015-2082-2

Year 2016

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_13594