Oncocin Onc110 analog c

General Information


DRACP ID  DRACP02696

Peptide Name   Oncocin Onc110 analog c

Sequence  VrKPPYLPRPRWxRxjYNX

Sequence Length  19

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
SH-SY5Y Neuroblastoma Blastoma 5% Cytotoxicity=600 µg/ml MTT assay 24 h 1
HeLa Human papillomavirus-related endocervical adenocarcinoma Carcinoma 10-20% Cytotoxicity=600 µg/ml MTT assay 24 h 1
HepG2 Hepatoblastoma Blastoma Not active up to 600 µg/ml MTT assay 24 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  HEK293: Not active up to 600 µg/ml

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  r=D-Arg; x=trans-4-hydroxyproline; X(16)=tert-Leu; X(19)=Orn

Chiral  Mix



Physicochemical Information


Formula  C88H122N26O13

Absent amino acids  ACDEFGHIMQST

Common amino acids  P

Mass  218331

Pl  11.47

Basic residues  4

Acidic residues  0

Hydrophobic residues  3

Net charge  4

Boman Index  -4594

Hydrophobicity  -120

Aliphatic Index  35.79

Half Life 
  /

Extinction Coefficient cystines  8480

Absorbance 280nm  471.11

Polar residues  3

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 26334348

Title  Optimization of oncocin for antibacterial activity using a SPOT synthesis approach: extending the pathogen spectrum to Staphylococcus aureus

Doi 10.1007/s00726-015-2082-2

Year  2016

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_13595

DRACP is developed by Dr.Zheng's team.