Oncocin Onc112 analog b

General Information


DRACP ID  DRACP02699

Peptide Name   Oncocin Onc112 analog b

Sequence  VXKPPYLPRPRWPRrIYNr

Sequence Length  19

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
SH-SY5Y Neuroblastoma Blastoma <10% Cytotoxicity=600 µg/ml MTT assay 24 h 1
HeLa Human papillomavirus-related endocervical adenocarcinoma Carcinoma 40% Cytotoxicity=601 µg/ml MTT assay 24 h 1
HepG2 Hepatoblastoma Blastoma 10% Cytotoxicity=600 µg/ml MTT assay 24 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  HEK293: 50-60% Cytotoxicity=600 µg/ml

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  r=D-Arg; X=Orn

Chiral  Mix



Physicochemical Information


Formula  C99H144N28O17

Absent amino acids  ACDEFGHMQST

Common amino acids  P

Mass  242962

Pl  11.47

Basic residues  4

Acidic residues  0

Hydrophobic residues  4

Net charge  4

Boman Index  -4102

Hydrophobicity  -104.74

Aliphatic Index  56.32

Half Life 
  /

Extinction Coefficient cystines  8480

Absorbance 280nm  471.11

Polar residues  3

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 26334348

Title  Optimization of oncocin for antibacterial activity using a SPOT synthesis approach: extending the pathogen spectrum to Staphylococcus aureus

Doi 10.1007/s00726-015-2082-2

Year  2016

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_13597

DRACP is developed by Dr.Zheng's team.