This work is licensed under a Creative Commons Attribution 4.0 International License.
2W-3
General Information
DRACP ID DRACP02704
Peptide Name 2W-3
Sequence RRLRKKTWKRLW
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| RAW 264.7 | Mouse leukemia | Leukemia | 10-15% Cytotoxicity=128 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: 5% Hemolysis>128 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C80H135N29O14
Absent amino acids ACDEFGHIMNPQSVY
Common amino acids R
Mass 192351
Pl 12.99
Basic residues 7
Acidic residues 0
Hydrophobic residues 4
Net charge 7
Boman Index -6440
Hydrophobicity -205
Aliphatic Index 65
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 11000
Absorbance 280nm 1000
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31276398
Title Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism
Doi 10.1021/acs.jmedchem.9b00288
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_13673
This work is licensed under a Creative Commons Attribution 4.0 International License.