This work is licensed under a Creative Commons Attribution 4.0 International License.
4W
General Information
DRACP ID DRACP02712
Peptide Name 4W
Sequence RWLRWWTRWRLK
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| RAW 264.7 | Mouse leukemia | Leukemia | 100% Cytotoxicity=128 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: 5% Hemolysis=128 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C90H131N29O14
Absent amino acids ACDEFGHIMNPQSVY
Common amino acids RW
Mass 203959
Pl 12.98
Basic residues 5
Acidic residues 0
Hydrophobic residues 6
Net charge 5
Boman Index -4864
Hydrophobicity -155
Aliphatic Index 65
Half Life
Mammalian: 5.5 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 22000
Absorbance 280nm 2000
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31276398
Title Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism
Doi 10.1021/acs.jmedchem.9b00288
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_13681
This work is licensed under a Creative Commons Attribution 4.0 International License.