4W

General Information


DRACP ID  DRACP02712

Peptide Name   4W

Sequence  RWLRWWTRWRLK

Sequence Length  12

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP Membrane lysis



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
RAW 264.7 Mouse leukemia Leukemia 100% Cytotoxicity=128 µM MTT assay 24 h 1

Hemolytic Activity  Human erythrocytes: 5% Hemolysis=128 µM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  Not available

Predicted Structure  DRACP02712

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C90H131N29O14

Absent amino acids  ACDEFGHIMNPQSVY

Common amino acids  RW

Mass  203959

Pl  12.98

Basic residues  5

Acidic residues  0

Hydrophobic residues  6

Net charge  5

Boman Index  -4864

Hydrophobicity  -155

Aliphatic Index  65

Half Life 
  Mammalian: 5.5 hour
  Yeast: 3 min
  E.coli: 2 min

Extinction Coefficient cystines  22000

Absorbance 280nm  2000

Polar residues  1

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 31276398

Title  Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism

Doi 10.1021/acs.jmedchem.9b00288

Year  2019

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_13681

DRACP is developed by Dr.Zheng's team.