This work is licensed under a Creative Commons Attribution 4.0 International License.
RTL
General Information
DRACP ID DRACP02716
Peptide Name RTL
Sequence WRLRWRTRWRLR
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| RAW 264.7 | Mouse leukemia | Leukemia | Not active up to 128 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: 5% Hemolysis>128 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C85H133N33O14
Absent amino acids ACDEFGHIKMNPQSVY
Common amino acids R
Mass 203757
Pl 13.2
Basic residues 6
Acidic residues 0
Hydrophobic residues 5
Net charge 6
Boman Index -7526
Hydrophobicity -190
Aliphatic Index 65
Half Life
Mammalian: 2.8 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 16500
Absorbance 280nm 1500
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31276398
Title Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism
Doi 10.1021/acs.jmedchem.9b00288
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_13685
This work is licensed under a Creative Commons Attribution 4.0 International License.