C12C3lexin, Ranalexin (7-20) C12

General Information


DRACP ID  DRACP02727

Peptide Name   C12C3lexin, Ranalexin (7-20) C12

Sequence  KIVPAMICAVTKKC

Sequence Length  14

UniProt ID  P39084 

PubChem CID  Not available

Origin  Synthetic (Derived from Ranalexin)

Type  Synthetic peptide

Classification

  

Active ACP Lipopeptides Membrane-targeted



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HepG2 Hepatoblastoma Blastoma IC50=19 µg/ml MTT assay 24 h 1
LNCaP C4-2 Prostate carcinoma Carcinoma IC50=15 µg/ml MTT assay 24 h 1
HeLa Human papillomavirus-related endocervical adenocarcinoma Carcinoma IC50=30 µg/ml MTT assay 24 h 1
MEC-7 Invasive breast carcinoma of no special type Carcinoma IC50=10 µg/ml MTT assay 24 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  CHO-K1: IC50=23 µg/ml; PBMC: IC50=20 µg/ml

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  Not available

Predicted Structure  DRACP02727

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Cys8<--->Cys14

N-terminal Modification  CH3(CH2)10CO, Dodecanoic acid

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C66H121N17O16S3

Absent amino acids  DEFGHLNQRSWY

Common amino acids  K

Mass  173705

Pl  9.67

Basic residues  3

Acidic residues  0

Hydrophobic residues  6

Net charge  3

Boman Index  723

Hydrophobicity  99.29

Aliphatic Index  111.43

Half Life 
  Mammalian: 1.3 hour
  Yeast: 3 min
  E.coli: 2 min

Extinction Coefficient cystines  125

Absorbance 280nm  9.62

Polar residues  3

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 29649587

Title  A novel tool against multiresistant bacterial pathogens: lipopeptide modification of the natural antimicrobial peptide ranalexin for enhanced antimicrobial activity and improved pharmacokinetics

Doi 10.1016/j.ijantimicag.2018.03.023

Year  2018

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_13800

DRACP is developed by Dr.Zheng's team.