This work is licensed under a Creative Commons Attribution 4.0 International License.
C10C3lexin, Ranalexin (7-20) C10
General Information
DRACP ID DRACP02729
Peptide Name C10C3lexin, Ranalexin (7-20) C10
Sequence KIVPAMICAVTKKC
Sequence Length 14
UniProt ID P39084
PubChem CID Not available
Origin Synthetic (Derived from Ranalexin)
Type Synthetic peptide
Classification
Active ACP Lipopeptides Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HepG2 | Hepatoblastoma | Blastoma | IC50=48 µg/ml | MTT assay | 24 h | 1 |
| LNCaP C4-2 | Prostate carcinoma | Carcinoma | IC50=35 µg/ml | MTT assay | 24 h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=36 µg/ml | MTT assay | 24 h | 1 |
| MEC-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=35 µg/ml | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity CHO-K1: IC50=40 µg/ml; PBMC: IC50=108.1 µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys8<--->Cys14
N-terminal Modification CH3(CH2)8CO, Decanoic acid
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C66H121N17O16S3
Absent amino acids DEFGHLNQRSWY
Common amino acids K
Mass 173705
Pl 9.67
Basic residues 3
Acidic residues 0
Hydrophobic residues 6
Net charge 3
Boman Index 723
Hydrophobicity 99.29
Aliphatic Index 111.43
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 125
Absorbance 280nm 9.62
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29649587
Title A novel tool against multiresistant bacterial pathogens: lipopeptide modification of the natural antimicrobial peptide ranalexin for enhanced antimicrobial activity and improved pharmacokinetics
Doi 10.1016/j.ijantimicag.2018.03.023
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_13802
This work is licensed under a Creative Commons Attribution 4.0 International License.