This work is licensed under a Creative Commons Attribution 4.0 International License.
G(LLKK)3L-NH2
General Information
DRACP ID DRACP02730
Peptide Name G(LLKK)3L-NH2
Sequence GLLKKLLKKLLKKL
Sequence Length 14
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 70% Killing=50 µM | MTT assay | 24 h | 1 |
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | Leukemia | >80% Killing=50 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: HC50=30 µM
Normal (non-cancerous) Cytotoxicity Human keratinocytes HaCat: >90% Killing=40 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C80H154N20O15
Absent amino acids ACDEFHIMNPQRSTVWY
Common amino acids L
Mass 186831
Pl 11.5
Basic residues 6
Acidic residues 0
Hydrophobic residues 7
Net charge 6
Boman Index 208
Hydrophobicity 20
Aliphatic Index 195
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Amino acid side chains affect the bioactivity of designed short peptide amphiphiles
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_13973
This work is licensed under a Creative Commons Attribution 4.0 International License.