G(IIOO)3I-NH2

General Information


DRACP ID  DRACP02733

Peptide Name   G(IIOO)3I-NH2

Sequence  GIIXXIIXXIIXXI

Sequence Length  14

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP Membrane-targeted



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HeLa Human papillomavirus-related endocervical adenocarcinoma Carcinoma >80% Killing=50 µM MTT assay 24 h 1
HL-60 Adult acute myeloid leukemia; Acute myeloid leukemia Leukemia >80% Killing=50 µM MTT assay 24 h 1

Hemolytic Activity  Human erythrocytes: HC50>250 µM

Normal (non-cancerous) Cytotoxicity  Human keratinocytes HaCat: <5% Killing=40 µM

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  X=Orn

Chiral  L



Physicochemical Information


Formula  C44H70N8O3

Absent amino acids  ACDEFHKLMNPQRSTVWY

Common amino acids  I

Mass  165117

Pl  6.11

Basic residues  0

Acidic residues  0

Hydrophobic residues  7

Net charge  0

Boman Index  3538

Hydrophobicity  222.14

Aliphatic Index  195

Half Life 
  /

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  1

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Amino acid side chains affect the bioactivity of designed short peptide amphiphiles

Doi 10.1039/C6TB00155F

Year  2016

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_13975

DRACP is developed by Dr.Zheng's team.