This work is licensed under a Creative Commons Attribution 4.0 International License.
G(II55)3I-NH2
General Information
DRACP ID DRACP02735
Peptide Name G(II55)3I-NH2
Sequence GIIXXIIXXIIXXI
Sequence Length 14
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | >80% Killing=50 µM | MTT assay | 24 h | 1 |
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | Leukemia | >80% Killing=50 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: HC50=200 µM
Normal (non-cancerous) Cytotoxicity Human keratinocytes HaCat: <5% Killing=40 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification X=Dap ((S)-2,3-diaminopropionic acid)
Chiral L
Physicochemical Information
Formula C44H70N8O3
Absent amino acids ACDEFHKLMNPQRSTVWY
Common amino acids I
Mass 165117
Pl 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 7
Net charge 0
Boman Index 3538
Hydrophobicity 222.14
Aliphatic Index 195
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Amino acid side chains affect the bioactivity of designed short peptide amphiphiles
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_13977
This work is licensed under a Creative Commons Attribution 4.0 International License.