HI2

General Information


DRACP ID  DRACP02736

Peptide Name   HI2

Sequence  RRIHIHIpGIHIHIRR

Sequence Length  16

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic (Derived from PG-1)

Type  Synthetic peptide

Classification

  

Active ACP Membrane lysis β-hairpin peptides



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
RAW 264.7 Mouse leukemia Leukemia 55% Killing=128 µM MTT assay 4 h 1

Hemolytic Activity  Human erythrocytes: 5% Hemolysis>128 µM

Normal (non-cancerous) Cytotoxicity  HEK 293T: 45% Killing=128 µM

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  p=D-Pro

Chiral  Mix



Physicochemical Information


Formula  C86H145N35O15

Absent amino acids  ACDEFKLMNPQSTVWY

Common amino acids  I

Mass  217707

Pl  12.98

Basic residues  8

Acidic residues  0

Hydrophobic residues  6

Net charge  8

Boman Index  -4786

Hydrophobicity  -26.25

Aliphatic Index  146.25

Half Life 
  /

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  1

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 31416220

Title  Bioactivity and Bactericidal Mechanism of Histidine-Rich β-Hairpin Peptide Against Gram-Negative Bacteria

Doi 10.3390/ijms20163954

Year  2019

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_13987

DRACP is developed by Dr.Zheng's team.