This work is licensed under a Creative Commons Attribution 4.0 International License.
HW2
General Information
DRACP ID DRACP02737
Peptide Name HW2
Sequence RRWHWHWpGWHWHWRR
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin Synthetic (Derived from PG-1)
Type Synthetic peptide
Classification
Active ACP Membrane lysis β-hairpin peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| RAW 264.7 | Mouse leukemia | Leukemia | 95% Killing=128 µM | MTT assay | 4 h | 1 |
Hemolytic Activity Human erythrocytes: 5% Hemolysis=8 µM
Normal (non-cancerous) Cytotoxicity HEK 293T: >95% Killing=128 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification p=D-Pro
Chiral Mix
Physicochemical Information
Formula C116H139N41O15
Absent amino acids ACDEFIKLMNPQSTVY
Common amino acids W
Mass 261537
Pl 12.98
Basic residues 8
Acidic residues 0
Hydrophobic residues 6
Net charge 8
Boman Index -6340
Hydrophobicity -228.75
Aliphatic Index 0
Half Life
/
Extinction Coefficient cystines 33000
Absorbance 280nm 2200
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31416220
Title Bioactivity and Bactericidal Mechanism of Histidine-Rich β-Hairpin Peptide Against Gram-Negative Bacteria
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_13988
This work is licensed under a Creative Commons Attribution 4.0 International License.