This work is licensed under a Creative Commons Attribution 4.0 International License.
PG-1, Protegrin-1
General Information
DRACP ID DRACP02740
Peptide Name PG-1, Protegrin-1
Sequence RGGRLCYCRRFCVCVGR
Sequence Length 17
UniProt ID Not available
PubChem CID Not available
Origin Neutrophils in pigs
Type Native peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| RAW 264.7 | Mouse leukemia | Leukemia | >95% Killing=128 µM | MTT assay | 4 h | 1 |
Hemolytic Activity Human erythrocytes: 5% Hemolysis=4 µM
Normal (non-cancerous) Cytotoxicity HEK 293T: 80% Killing=128 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification p=D-Pro
Chiral L
Physicochemical Information
Formula C82H138N32O19S4
Absent amino acids ADEHIKMNPQSTW
Common amino acids R
Mass 229001
Pl 9.72
Basic residues 5
Acidic residues 0
Hydrophobic residues 4
Net charge 5
Boman Index -5082
Hydrophobicity 0
Aliphatic Index 57.06
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 1740
Absorbance 280nm 108.75
Polar residues 8
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31416220
Title Bioactivity and Bactericidal Mechanism of Histidine-Rich β-Hairpin Peptide Against Gram-Negative Bacteria
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.