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YYS
General Information
DRACP ID DRACP02744
Peptide Name YYS
Sequence YEEYSKKYEEYSKKYEEYSKKYEEYSKKYEEYSKKXK
Sequence Length 37
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Lipopeptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Huh-7 | Adult hepatocellular carcinoma; Adult hepatocellular carcinoma | Carcinoma | CC50=19.8±1.6 µM | CCK-8 assay | 48 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antiviral
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Acetylation
C-terminal Modification CH3(CH2)14CONH2, Hexadecanamide
Other Modification X= β-Ala
Chiral L
Physicochemical Information
Formula C221H317N47O71
Absent amino acids ACDFGHILMNPQRTVW
Common amino acids K
Mass 552044
Pl 8.68
Basic residues 11
Acidic residues 10
Hydrophobic residues 0
Net charge 1
Boman Index -14755
Hydrophobicity -256.49
Aliphatic Index 0
Half Life
/
Extinction Coefficient cystines 14900
Absorbance 280nm 413.89
Polar residues 15
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30192544
Title De Novo Design of α-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery
Doi 10.1021/acs.jmedchem.8b00890
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_15187
This work is licensed under a Creative Commons Attribution 4.0 International License.