This work is licensed under a Creative Commons Attribution 4.0 International License.
HR2PM2
General Information
DRACP ID DRACP02753
Peptide Name HR2PM2
Sequence SLTQINTTLLDLEYEMKKLEEVVKKLEESYIDLKEL
Sequence Length 36
UniProt ID K9N5Q8
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Lipopeptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Huh-7 | Adult hepatocellular carcinoma; Adult hepatocellular carcinoma | Carcinoma | CC50>100 µM | CCK-8 assay | 48 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antiviral
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C193H321N43O64S
Absent amino acids ACFGHPRW
Common amino acids L
Mass 492446
Pl 4.19
Basic residues 5
Acidic residues 9
Hydrophobic residues 12
Net charge -4
Boman Index -6020
Hydrophobicity -40.56
Aliphatic Index 124.44
Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 2980
Absorbance 280nm 85.14
Polar residues 8
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30192544
Title De Novo Design of α-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery
Doi 10.1021/acs.jmedchem.8b00890
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_15196
This work is licensed under a Creative Commons Attribution 4.0 International License.