This work is licensed under a Creative Commons Attribution 4.0 International License.
Helical1
General Information
DRACP ID DRACP02758
Peptide Name Helical1
Sequence FLWIKLGKLAGAVLKLILGLKKVV
Sequence Length 24
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | EC50=4.4 ± 1.3 µM | MTT assay | 24 h | 1 |
| A549 | Lung adenocarcinoma | Carcinoma | EC50=8.3 ± 2.0 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C131H226N30O25
Absent amino acids CDEHMNPQRSTY
Common amino acids L
Mass 303189
Pl 11.4
Basic residues 5
Acidic residues 0
Hydrophobic residues 16
Net charge 5
Boman Index 4040
Hydrophobicity 137.5
Aliphatic Index 190.83
Half Life
Mammalian: 5.5 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 239.13
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31375699
Title In silico design and optimization of selective membranolytic anticancer peptides
Doi 10.1038/s41598-019-47568-9
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_16625
This work is licensed under a Creative Commons Attribution 4.0 International License.