This work is licensed under a Creative Commons Attribution 4.0 International License.
AmphiArc1
General Information
DRACP ID DRACP02762
Peptide Name AmphiArc1
Sequence KWVKKVHNWLRRWIKVFEALFG
Sequence Length 22
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | EC50=7.0 ± 0.5 µM | MTT assay | 24 h | 1 |
| A549 | Lung adenocarcinoma | Carcinoma | EC50=18.4 ± 0.7 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C140H210N38O26
Absent amino acids CDMPQSTY
Common amino acids K
Mass 321620
Pl 11.82
Basic residues 7
Acidic residues 1
Hydrophobic residues 12
Net charge 6
Boman Index -2757
Hydrophobicity -26.36
Aliphatic Index 97.27
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 16500
Absorbance 280nm 785.71
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31375699
Title In silico design and optimization of selective membranolytic anticancer peptides
Doi 10.1038/s41598-019-47568-9
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_16626
This work is licensed under a Creative Commons Attribution 4.0 International License.