This work is licensed under a Creative Commons Attribution 4.0 International License.
Gradient2
General Information
DRACP ID DRACP02767
Peptide Name Gradient2
Sequence AWLKRIKKFLKALFWVWVW
Sequence Length 19
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | EC50=19.0 ± 1.8 µM | MTT assay | 24 h | 1 |
| A549 | Lung adenocarcinoma | Carcinoma | EC50>50 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C132H192N30O20
Absent amino acids CDEGHMNPQSTY
Common amino acids KW
Mass 284042
Pl 12
Basic residues 5
Acidic residues 0
Hydrophobic residues 14
Net charge 5
Boman Index 954
Hydrophobicity 51.58
Aliphatic Index 123.16
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 22000
Absorbance 280nm 1222.22
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31375699
Title In silico design and optimization of selective membranolytic anticancer peptides
Doi 10.1038/s41598-019-47568-9
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_16627
This work is licensed under a Creative Commons Attribution 4.0 International License.