This work is licensed under a Creative Commons Attribution 4.0 International License.
AmphiArc2 Off9
General Information
DRACP ID DRACP02778
Peptide Name AmphiArc2 Off9
Sequence KLIHRLKTVFKKVWHFLGHL
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | EC50=18.9 ± 0.2 µM | MTT assay | 24 h | 1 |
| A549 | Lung adenocarcinoma | Carcinoma | EC50=22 ± 4 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: HC50=41 ± 3 µM
Normal (non-cancerous) Cytotoxicity HDMEC: EC50=22 ± 3 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C123H194N34O22
Absent amino acids ACDEMNPQSY
Common amino acids KL
Mass 284020
Pl 12
Basic residues 8
Acidic residues 0
Hydrophobic residues 10
Net charge 8
Boman Index -1176
Hydrophobicity 10
Aliphatic Index 126.5
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 289.47
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31375699
Title In silico design and optimization of selective membranolytic anticancer peptides
Doi 10.1038/s41598-019-47568-9
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_16603
This work is licensed under a Creative Commons Attribution 4.0 International License.