This work is licensed under a Creative Commons Attribution 4.0 International License.
AmphiArc2 Off2.9
General Information
DRACP ID DRACP02788
Peptide Name AmphiArc2 Off2.9
Sequence HLIHRLHTYWHKPWHYLGKL
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | EC50>100 µM | MTT assay | 24 h | 1 |
| A549 | Lung adenocarcinoma | Carcinoma | EC50>100 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: HC50>200 µM
Normal (non-cancerous) Cytotoxicity HDMEC: EC50=135 ± 2 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C129H183N37O24
Absent amino acids ACDEFMNQSV
Common amino acids H
Mass 297520
Pl 10.45
Basic residues 8
Acidic residues 0
Hydrophobic residues 7
Net charge 8
Boman Index -2197
Hydrophobicity -78.5
Aliphatic Index 97.5
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 13980
Absorbance 280nm 735.79
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31375699
Title In silico design and optimization of selective membranolytic anticancer peptides
Doi 10.1038/s41598-019-47568-9
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_16613
This work is licensed under a Creative Commons Attribution 4.0 International License.