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CDAK
General Information
DRACP ID DRACP02800
Peptide Name CDAK
Sequence CXGRCLLIIKLAKLAKKLAKLAK
Sequence Length 23
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Cancer targeted peptides Coupling peptide Induce apoptosis Antiangiogenic Proliferation inhibition
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=190 µg/ml | MTT assay | 24 h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50=212 µg/ml | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HUVEC: IC50=861 µg/ml; HFF: IC50=912 µg/ml
Target CD13-/αvβ3+ tumor cells
Affinity Not available
Mechanism AMPs containing CisoDGRC selectively kill CD13-/αvβ3+ breast cancer cells by inducing apoptosis and inhibiting proliferation. Furthermore, the vivo experiments showed that AMPs containing CisoDGRC could significantly inhibited CD13-/αvβ3+ tumor progression and angiogenesis.
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys1<--->Cys5
N-terminal Modification Free
C-terminal Modification Free
Other Modification X=iso-Asp
Chiral L
Physicochemical Information
Formula C110H205N31O22S2
Absent amino acids DEFHMNPQSTVWY
Common amino acids KL
Mass 288079
Pl 11.09
Basic residues 7
Acidic residues 0
Hydrophobic residues 12
Net charge 7
Boman Index 188
Hydrophobicity 68.26
Aliphatic Index 153.04
Half Life
/
Extinction Coefficient cystines 125
Absorbance 280nm 5.68
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23326440
Title Antitumor Activity of Antimicrobial Peptides Containing CisoDGRC in CD13 Negative Breast Cancer Cells
Doi 10.1371/journal.pone.0053491
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_16628
This work is licensed under a Creative Commons Attribution 4.0 International License.