This work is licensed under a Creative Commons Attribution 4.0 International License.
ChBac3.4-COOH
General Information
DRACP ID DRACP02802
Peptide Name ChBac3.4-COOH
Sequence RFRLPFRRPPIRIHPPPFYPPFRRFL
Sequence Length 26
UniProt ID P85170
PubChem CID Not available
Origin Capra hircus
Type Synthetic peptide
Classification
Active ACP Induce apoptosis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | Leukemia | IC50=24.4 ± 4.0 μM | MTT assay | overnight | 1 |
| U-937 | Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia | Leukemia | IC50=12.9 ± 0.3 μM | MTT assay | overnight | 1 |
Hemolytic Activity Human erythrocytes: <5% Hemolysis=64 µM
Normal (non-cancerous) Cytotoxicity Human PBMC: IC50=36.2 ± 6.9 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C166H247N49O28
Absent amino acids ACDEGKMNQSTVW
Common amino acids P
Mass 382314
Pl 12.9
Basic residues 8
Acidic residues 0
Hydrophobic residues 9
Net charge 8
Boman Index -7466
Hydrophobicity -70
Aliphatic Index 60
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 1490
Absorbance 280nm 59.6
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33194795
Title Caprine Bactenecins as Promising Tools for Developing New Antimicrobial and Antitumor Drugs
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_16644
This work is licensed under a Creative Commons Attribution 4.0 International License.