Peptide Libraray

RFR-ChBac3.4-1-NH2

General Information

DRACP ID DRACP02805

Peptide Name RFR-ChBac3.4-1-NH2

Sequence RFRRFRLPFRRIHPPPFVRIHPPPFYRRFL

Sequence Length 30

UniProt ID P85170

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Active ACP Induce apoptosis

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
K562	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia	Leukemia	IC50=20.0 ± 3.4 μM	MTT assay	overnight	1
U-937	Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia	Leukemia	IC50=3.2 ± 0.4 μM	MTT assay	overnight	1

Hemolytic Activity Human erythrocytes: <5% Hemolysis=64 µM

Normal (non-cancerous) Cytotoxicity Human PBMC: IC50=18.3 ± 4.1 µM

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antibacterial

Structure Information

PDB ID Not available

Predicted Structure DRACP02805

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C193H289N61O32

Absent amino acids ACDEGKMNQSTW

Common amino acids R

Mass 449319

Pl 13.04

Basic residues 11

Acidic residues 0

Hydrophobic residues 11

Net charge 11

Boman Index -10214

Hydrophobicity -72.67

Aliphatic Index 61.67

Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min

Extinction Coefficient cystines 1490

Absorbance 280nm 51.38

Polar residues 1

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 33194795

Title Caprine Bactenecins as Promising Tools for Developing New Antimicrobial and Antitumor Drugs

Doi 10.3389/fcimb.2020.552905

Year 2020

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_16647