ChBac3.4 (1-14)-NH2

General Information


DRACP ID  DRACP02810

Peptide Name   ChBac3.4 (1-14)-NH2

Sequence  RFRLPFRRPPIRIH

Sequence Length  14

UniProt ID  P85170 

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP Induce apoptosis



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
K562 Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia Leukemia IC50=33.6 ± 4.1 μM MTT assay overnight 1
U-937 Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia Leukemia IC50>64 μM MTT assay overnight 1

Hemolytic Activity  Human erythrocytes: <5% Hemolysis=64 µM

Normal (non-cancerous) Cytotoxicity  Human PBMC: IC50>64 µM

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  Not available

Predicted Structure  DRACP02810

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C87H141N31O15

Absent amino acids  ACDEGKMNQSTVWY

Common amino acids  R

Mass  209331

Pl  13.1

Basic residues  6

Acidic residues  0

Hydrophobic residues  5

Net charge  6

Boman Index  -5854

Hydrophobicity  -86.43

Aliphatic Index  83.57

Half Life 
  Mammalian: 1 hour
  Yeast: 2 min
  E.coli: 2 min

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  0

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 33194795

Title  Caprine Bactenecins as Promising Tools for Developing New Antimicrobial and Antitumor Drugs

Doi 10.3389/fcimb.2020.552905

Year  2020

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_16652

DRACP is developed by Dr.Zheng's team.