This work is licensed under a Creative Commons Attribution 4.0 International License.
RFR-ChBac3.4 (1-14)-NH2
General Information
DRACP ID DRACP02811
Peptide Name RFR-ChBac3.4 (1-14)-NH2
Sequence RFRRFRLPFRRPPIRIH
Sequence Length 17
UniProt ID P85170
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Induce apoptosis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | Leukemia | IC50=39.4 ± 6.6 μM | MTT assay | overnight | 1 |
| U-937 | Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia | Leukemia | IC50>64 μM | MTT assay | overnight | 1 |
Hemolytic Activity Human erythrocytes: <5% Hemolysis=64 µM
Normal (non-cancerous) Cytotoxicity Human PBMC: IC50>64 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C108H174N40O18
Absent amino acids ACDEGKMNQSTVWY
Common amino acids R
Mass 260636
Pl 13.28
Basic residues 8
Acidic residues 0
Hydrophobic residues 6
Net charge 8
Boman Index -8540
Hydrophobicity -107.65
Aliphatic Index 68.82
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33194795
Title Caprine Bactenecins as Promising Tools for Developing New Antimicrobial and Antitumor Drugs
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_16653
This work is licensed under a Creative Commons Attribution 4.0 International License.