This work is licensed under a Creative Commons Attribution 4.0 International License.
Modifed Coco1
General Information
DRACP ID DRACP02812
Peptide Name Modifed Coco1
Sequence FTILKKLKSFIK
Sequence Length 12
UniProt ID I0YNC0
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | CC50>200 μM | MTT assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: <10% Hemolysis=50 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C73H124N16O15
Absent amino acids ACDEGHMNPQRVWY
Common amino acids K
Mass 166227
Pl 11.28
Basic residues 4
Acidic residues 0
Hydrophobic residues 6
Net charge 4
Boman Index -253
Hydrophobicity 42.5
Aliphatic Index 130
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33063186
Title Design of antimicrobial and cytolytic peptides by computational analysis of bacterial, algal, and invertebrate proteomes
Doi 10.1007/s00726-020-02900-w
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_16906
This work is licensed under a Creative Commons Attribution 4.0 International License.