This work is licensed under a Creative Commons Attribution 4.0 International License.
Modifed Coco2
General Information
DRACP ID DRACP02813
Peptide Name Modifed Coco2
Sequence KLVKKLLKKYITF
Sequence Length 13
UniProt ID I0Z3W2
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | CC50=200 μM | MTT assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: <10% Hemolysis=50 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C81H140N18O16
Absent amino acids ACDEGHMNPQRSW
Common amino acids K
Mass 183634
Pl 11.02
Basic residues 5
Acidic residues 0
Hydrophobic residues 6
Net charge 5
Boman Index -376
Hydrophobicity 10.77
Aliphatic Index 142.31
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 1490
Absorbance 280nm 124.17
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33063186
Title Design of antimicrobial and cytolytic peptides by computational analysis of bacterial, algal, and invertebrate proteomes
Doi 10.1007/s00726-020-02900-w
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_16907
This work is licensed under a Creative Commons Attribution 4.0 International License.