This work is licensed under a Creative Commons Attribution 4.0 International License.
Modifed Coco3
General Information
DRACP ID DRACP02814
Peptide Name Modifed Coco3
Sequence LARFVLRILKYGFK
Sequence Length 14
UniProt ID I0YQ90
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | CC50=12.5 μM | MTT assay | 24 h | 1 |
| CaCo-2 | Colon adenocarcinoma | Carcinoma | CC50=25 μM | MTT assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: 10% Hemolysis=9.38 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C85H138N22O16
Absent amino acids CDEHMNPQSTW
Common amino acids L
Mass 195623
Pl 11.68
Basic residues 4
Acidic residues 0
Hydrophobic residues 8
Net charge 4
Boman Index -865
Hydrophobicity 64.29
Aliphatic Index 139.29
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 1490
Absorbance 280nm 114.62
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33063186
Title Design of antimicrobial and cytolytic peptides by computational analysis of bacterial, algal, and invertebrate proteomes
Doi 10.1007/s00726-020-02900-w
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_16908
This work is licensed under a Creative Commons Attribution 4.0 International License.