This work is licensed under a Creative Commons Attribution 4.0 International License.
Modifed Opero1
General Information
DRACP ID DRACP02815
Peptide Name Modifed Opero1
Sequence IPLLRKGKKIIWW
Sequence Length 13
UniProt ID A0A0L7KPW9
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | CC50>200 μM | MTT assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: <10% Hemolysis=50 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C83H135N21O14
Absent amino acids ACDEFHMNQSTVY
Common amino acids IK
Mass 186535
Pl 11.92
Basic residues 4
Acidic residues 0
Hydrophobic residues 7
Net charge 4
Boman Index -137
Hydrophobicity 8.46
Aliphatic Index 150
Half Life
Mammalian: 5.5 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 11000
Absorbance 280nm 916.67
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33063186
Title Design of antimicrobial and cytolytic peptides by computational analysis of bacterial, algal, and invertebrate proteomes
Doi 10.1007/s00726-020-02900-w
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_16909
This work is licensed under a Creative Commons Attribution 4.0 International License.