This work is licensed under a Creative Commons Attribution 4.0 International License.
Modifed Pyro1
General Information
DRACP ID DRACP02818
Peptide Name Modifed Pyro1
Sequence IVIKSLGKFLKNVGGFAG
Sequence Length 18
UniProt ID O58222
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | CC50>200 μM | MTT assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: <10% Hemolysis=50 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C88H146N22O21
Absent amino acids CDEHMPQRTWY
Common amino acids G
Mass 215168
Pl 11.1
Basic residues 3
Acidic residues 0
Hydrophobic residues 9
Net charge 3
Boman Index 1260
Hydrophobicity 82.22
Aliphatic Index 124.44
Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33063186
Title Design of antimicrobial and cytolytic peptides by computational analysis of bacterial, algal, and invertebrate proteomes
Doi 10.1007/s00726-020-02900-w
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_16912
This work is licensed under a Creative Commons Attribution 4.0 International License.