Modifed Pyro1

General Information


DRACP ID  DRACP02818

Peptide Name   Modifed Pyro1

Sequence  IVIKSLGKFLKNVGGFAG

Sequence Length  18

UniProt ID  O58222 

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP Membrane-targeted



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
A549 Lung adenocarcinoma Carcinoma CC50>200 μM MTT assay 24 h 1

Hemolytic Activity  Human erythrocytes: <10% Hemolysis=50 µM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  Not available

Predicted Structure  DRACP02818

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C88H146N22O21

Absent amino acids  CDEHMPQRTWY

Common amino acids  G

Mass  215168

Pl  11.1

Basic residues  3

Acidic residues  0

Hydrophobic residues  9

Net charge  3

Boman Index  1260

Hydrophobicity  82.22

Aliphatic Index  124.44

Half Life 
  Mammalian: 20 hour
  Yeast: 30 min
  E.coli: >10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  6

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 33063186

Title  Design of antimicrobial and cytolytic peptides by computational analysis of bacterial, algal, and invertebrate proteomes

Doi 10.1007/s00726-020-02900-w

Year  2020

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_16912

DRACP is developed by Dr.Zheng's team.