Modifed Aper1

General Information


DRACP ID  DRACP02819

Peptide Name   Modifed Aper1

Sequence  FKLVWKLLKKLALKL

Sequence Length  15

UniProt ID  Q9Y8Y1 

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP Membrane-targeted



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
A549 Lung adenocarcinoma Carcinoma CC50=25 μM MTT assay 24 h 1
CaCo-2 Colon adenocarcinoma Carcinoma CC50=12.5 μM MTT assay 24 h 1

Hemolytic Activity  Human erythrocytes: 10% Hemolysis=5.96 µM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  Not available

Predicted Structure  DRACP02819

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C94H161N21O16

Absent amino acids  CDEGHIMNPQRSTY

Common amino acids  L

Mass  209136

Pl  11.4

Basic residues  5

Acidic residues  0

Hydrophobic residues  10

Net charge  5

Boman Index  1293

Hydrophobicity  74.67

Aliphatic Index  182

Half Life 
  Mammalian: 20 hour
  Yeast: 30 min
  E.coli: >10 hour

Extinction Coefficient cystines  5500

Absorbance 280nm  392.86

Polar residues  0

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 33063186

Title  Design of antimicrobial and cytolytic peptides by computational analysis of bacterial, algal, and invertebrate proteomes

Doi 10.1007/s00726-020-02900-w

Year  2020

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_16913

DRACP is developed by Dr.Zheng's team.