This work is licensed under a Creative Commons Attribution 4.0 International License.
Modifed Thermo3
General Information
DRACP ID DRACP02822
Peptide Name Modifed Thermo3
Sequence LFSIIWKLNRKLIKA
Sequence Length 15
UniProt ID B6YWQ6
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | CC50>200 μM | MTT assay | 24 h | 1 |
| CaCo-2 | Colon adenocarcinoma | Carcinoma | CC50>200 μM | MTT assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: 10% Hemolysis=37.3 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C90H151N23O18
Absent amino acids CDEGHMPQTVY
Common amino acids IKL
Mass 209324
Pl 11.92
Basic residues 4
Acidic residues 0
Hydrophobic residues 9
Net charge 4
Boman Index -497
Hydrophobicity 54
Aliphatic Index 162.67
Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 392.86
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33063186
Title Design of antimicrobial and cytolytic peptides by computational analysis of bacterial, algal, and invertebrate proteomes
Doi 10.1007/s00726-020-02900-w
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_16916
This work is licensed under a Creative Commons Attribution 4.0 International License.